Hataraku Saibou - Tumblr Posts
It’s been ages since I posted here. This fandom is probably dead, but have my favourite anime ship in history.
@heckthis-heckallofthis WHY THE F*CK did I look up your profile? WHY THE F*CK did I read Cells at Work White? I’m now simping for NEUTROPHILS of all things! I had no idea that this manga had so many spin-offs. I now have to read them all and I have physiology exams next week... which is a good thing, because Peyer’s patches and M cells are going to be important for the test hehe. So, because the neutrophil simps (and I am one now as well) gave me the inspiration to study, I’m gonna show you this doodle of U-1146 carrying platelets, but to scale. Neutrophils are 5 times larger than platelets on average and I needed this cuteness. Sorry, that his uniform is kinda wonky, I was drawing him from memory during physiology lectures.
I drew the little NYU-NYU, I mean, lactic acid bacterium during today’s microbiology class.
WE HAVE SOLVED THE MYSTERY OF WHY CELLS HATE NEUTROPHILS SO MUCH IN CAW
So, last night, my boyfriend and I got into some random discussion about programmed cell death and some new breakthroughs in medicine, you know, the usual things you talk about with your boyfriend at 1 AM. It is well known that leftover bodies of dead cells are phagocytosed (literally consumed) by macrophages. And that’s why I always wondered why aren’t cells scared of macrophages as much as they are of neutrophils, since neutrophils don’t consume the dead cells. With my limited understanding of immunity (which we technically don’t learn a lot about in biology) I thought that neutrophils only consumed invader bacteria and fungi.
And OH BOY was I wrong about that.
Because (and yes I have spent whole night researching this, I’ll provide the links to papers in the end lol) neutrophils are little freaks and not only do they phagocytose leftovers of cells they actually cause them to die in the first place. This happens during infections, especially with viruses that cause the excess release of cytokines (like Coronaviridae). Cytokines activate neutrophils who basically just follow the signal towards the infection site and there all hell breaks loose. Neutrophils phagocytose bacteria and virions (those are viruses that haven’t infected a cell yet) which is fine, but they also degranulate and NETose. I’ll explain this in simple terms to my best ability.
Degranulation is when granulocytes (neutrophils, eosinophils, basophils and mastocytes are all different granulocytes) release their granules which are kind of like little sacks inside their cytoplasm which contain various chemicals. Releasing these chemicals happens when the cell receives appropriate stimulus, the little granules expel their contents out of the cell’s interior. In the case of neutrophils, granules contain very toxic compounds that cause the formation of free radicals which damage DNA and proteins of the surrounding cells, as well as granules filled with digestive enzymes which, well, digest the surrounding tissues.
NETosis is a special type of cell death specific to neutrophils in which they literally degranulate pieces of their own, or their mitochondrial DNA together with more toxic compounds. This creates a net of DNA strands called chromatin which entangles invading bacteria and severely damages them and also marks them for phagocytosis by macrophages. But this process is not well controlled and some of that chromatin and toxic compounds can land onto neighboring cells which is, as you can conclude, very bad for them.
With these two abilities at hand, neutrophils are very well equipped to kill cells and destroy tissue. Which is good in cases when the cells are infected and the tissue is damaged, but their quite aggressive methods can damage healthy cells in the area as well, some of them will die and neutrophils will phagocytose their dead particles.
Basically, to neutrophils every infection is a huge kill and eat all you can buffet. They literally phagocytose until they physically cannot anymore and then go to the spleen or bone marrow to die. They also allow macrophages to consume them and thus pass on the antigens for antigen presentation which influences further immune response. But they can also cause a lot of damage, especially if cytokine storm happens and they completely lose control. This is what causes SARS and it can kill you if it’s severe enough.
Biologically speaking, neutrophils are very important because they are the first ones to come to the sight of infection and their crazy methods usually finish the things before they get too severe. They themselves produce cytokines that mobilize macrophages and dendritic cells so that more immune cells can join and help them. They also have a role in repairing the tissues they damaged.
However, other immune cells, including macrophages and killer T cells, simply don’t cause as much damage. Neutrophils just go all out, which is why they live for such a short period of time compared to their colleagues (they live for only few days, compared to macrophages who can live up to a month and lymphocytes who can live for months, even years).
So, yeah, my boyfriend and I have concluded (at 4AM this morning) that neutrophils are so feared because they damage tissue, go crazy and violently kill healthy cells by accident, then consume them and that’s not by accident, it’s a mechanism to repair tissues.
I can’t believe I wasted whole night just for this. My boyfriend is also disappointed. But I hope that we finally have an explanation for this mystery. Tell me what you think lol.
References:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589350/
https://www.nature.com/articles/nri.2017.105
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820392/#:~:text=Neutrophils%20contribute%20to%20tissue%20injury,detail%20here%20(Kruger%20et%20al.
Dear Tumblr, I have officially lost my mind. I genuinely watched this anime as a meme and now I’m making detailed fanart for the memes. I just can’t believe I ship fucking cells and simp for a fucking neutrophil. So, yeah, I hope you like this.
I was warming up my hand for some serious eldritch horror painting and for some reason drew him. I love him lol.
Dear Cells at Work fandom, I’m going on a vacation which means that I’ll be on hiatus here for like 10 days, so have this art I made out of boredom. This is the neutrophil from “Cells at Work and Friends” protecting his Red Blood Cell :)
Something old that layed around on a post it
Heyyy, sorry for not being active like, at all this month. I was very sick and was also preparing for some final exams (and I was not as successful as I hoped to be).
Anyways, I drew this last night out of boredom and I love it a lot.
YES I SURVIVED PNEUMOCOCCAL INFECTION AND MADE A CELLS AT WORK COMIC ABOUT IT BECAUSE I CAN!
The original Cells at work and all its characters belong to Akane Shimizu!!!
I am too dumb to draw mangas, so read left to right:
To explain some shit:
1. I had azithromycin because I’m kinda allergic to penicillin and I researched how it works. Basically, lots of the antibiotic collects inside the granules of phagocytes (aka. macrophages and neutrophils) and then they de-granulate upon encountering bacteria and fuck them up. Degranulation in Cells at Work is represented with their weapons, hence they got cool new weapon!
2. Azithromycin is a bacteriostatic which means that it causes them to stop reproducing and blocks their protein production. “Molecular machinery” refers to bacterial ribosomes, DNA and other components necessary for protein production.
3. The pills I got were light blue, so I made the antibiotic into blue lightsabers because I can and it’s cool.
4. I had to ship 1146 and 3803. I just had, sorry not sorry.
5. My artstyle is shit for Cells at work, but I don’t care one bit. I’m going to disappear from Tumblr for a little while to work on my actual webcomic that looks decent in this shit artstyle.
6. Yes I was sick for two weeks, it was most likely acute Streptococcus pneumoniae sinus infection. And I also got conjunctivitis, because of course I did. I’m fine now and this comic served as a very good catharsis.
I forgot why I love this fandom so much lmao.
Imagine being like a normal cell in the body, knowing absolutely nothing about like red blood cells or white blood cells so you get freaked out when a red blood cell throws up their literal mitochondria and a white blood cell eats it. I would commit apoptosis right there
Reblogging, cuz this is the only way I could learn biochemistry
uhhhh
They kiss :3
Here They are holding hands and having some Christmas candy!
This image was the reference lmao
I just want Cells at work fanfics and art but I.cant.find.anymore.
I scanned everywhere and
IM STILL HUNGRY FOR MORE
Where do pink blood cells come from?
Pink Blood Cell: Macrophage, where do pink blood cells come from?
Macrophage: Well, when a red blood cell and a white blood cell love each other very much, they-
AE3803 & U-1146: *in unison after arriving at the bone marrow to visit pink blood cell* NO! WAIT STOP!!!
Macrophage: Oh my, oh my, it seems that your parents have come to visit you.
Pink Blood Cell: *runs to hug AE3803 & U-1146* Mommy, Daddy!
AE3803: *sighs in relief* That's a close one.
U-1146: There's two things I will always protect: this world and our child's innocence.
Macrophage: My, my, I'm sorry, how improper of me. I couldn't resist answering a question from a little cell like him/her.
AE3803: I think it's best to tell him/her when he/she's all grown up.
Pink Blood Cell: Mommy, mommy, where do pink blood cells like me come from?
AE3803: When you're older dear.
Pink Blood Cell: But moooooom.
U-1146: Always listen to your mother, little cell.
Pink Blood Cell: Okay, daddy.
SIR PLEASE I-
U-1146 ain’t taking any of that shit anymore